Another One for William Stafford

Compassion for one reduces punishment for another

Give Me Another One!

We investigate the complexity of an optimization problem in Boolean propositional logic related to information theory: Given a conjunctive formula over a set of relations, find a satisfying assignment with minimal Hamming distance to a given assignment that satisfies the formula (NearestOtherSolution, NOSol). We present a complete classification with respect to the relations admitted in the for...

One thing leads to another.

In 1956, the JCI published an article by Vincent Dole on a method for titrating plasma fatty acids that uncovered the importance of fatty acids as a substrate for glucose metabolism. When asked to prepare a historical perspective on this very popular paper, I paid Dole a visit and we reminisced. His answer to my question of how he came to do this work on plasma fatty acids was: "Well, one thing...

Separating one organic from another

Env’s transmembrane domain revealed HIV-1’s envelope protein (Env) spans the viral membrane and grants the virus entry into host cells. Env is also the sole protein of HIV-1 that is targeted by antibodies, making it a key target for vaccine design. Dev et al. used nuclear magnetic resonance to determine an atomic-level structure of the membrane-spanning region of Env in a lipid bicelle. Env’s t...

Justice for Women : Stafford Borough , 1880 - 1905